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Chemically labile linkers are widely used in ADC clinical pipelines, with acid-sensitive linkers (such as hydrazones and silyl ethers) and disulfide linkers leading the field

Dexpramipexole also prevented functional decline in a dose dependent manner compared to placebo (Cudkowicz et al., 2011)

As shown in Figure 8E , genes related to base excision repair and pyrimidine metabolism, apoptotic process, and ribosome and thermogenesis formed the three main cores of the network

Jul 2009;3(4):635-643